COMPLEMENT FIXATION IN DISEASED TISSUES

Complement Fixation in Diseased Tissues

An immunohistologic complement fixation test has been used in an effort to detect immune complexes in sections of kidney from rats injected with rabbit anti-rat kidney serum and in sections of biopsied kidneys from four humans with membranous glomerulonephritis. Sections of the rat and human kidneys were treated with fluorescein-conjugated anti-rabbit globulin or antihuman globulin respectively...

Indirect Complement Fixation in Foot-and-Mouth Disease

COMPLEMENT FIXATION IN DISEASED TISSUES I. FIXATION OF GUINEA PIG COMPLEMENT IN SECTIONS OF KIDNEY FRO~[ HUMANS WITH MEMBRANOUS GLOMERULONEPttRITIS AND RATS INJECTED WITH ANTI-RAT KIDNEY SERUM*~ BY

The means by which interaction of antigen and antibody may lead to disease is not well understood. Arthus (1) observed that repeated subcutaneous injections of horse serum in rabbits elicited progressively severe local inflammatory reaction. From clinical observations on serum disease in man yon Pirquet (2) suggested "that a disease might be due indirectly to an antibody" and he coined the term...

Transcriptomes in healthy and diseased gingival tissues.

BACKGROUND Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobiology of periodontitis and would inform the design of future studies. METHOD...

Complement Fixation Tests in Pertussis.

Bordet and Gengou (1), in 1906, performed serological tests on pertussis employing the organisms which they discovered and claimed to be the causative agent of whooping cough as the antigen for the complement fixation test. They got a positive reaction in most cases of the disease. Yet, later investigations failed to confirm these results. Among those who confirmed their results were Renaux (2)...